解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::To study the effects of compressive straining on muscle cell deformation and damage an in vitro model system was developed. Myoblasts were seeded in agarose constructs and cultured in growth medium for 4 days. Subsequently, the cells were allowed to fuse into multinucleated myotubes for 8 days in differentiation mediu...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1349698
更新日期:2001-02-01 00:00:00
abstract::The aim of this study was to develop an empirical model of parameter-based gait data, based on an artificial neural network and a genetic algorithm, for the assessment of patients after ankle arthrodesis. Ground reaction force vectors were measured by force platforms during level walking. Nine force parameters express...
journal_title:Annals of biomedical engineering
pub_type: 临床试验,杂志文章
doi:10.1114/1.1342053
更新日期:2001-01-01 00:00:00
abstract::When cells and the matrix of a tissue remodel, the mechanical properties of the tissue do change. The mechanical properties are expressed by constitutive equations. In this article the remodeling of the constitutive equation of the pulmonary artery is studied. The remodeling was induced in a rat breathing a gas whose ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1380417
更新日期:2001-01-01 00:00:00
abstract::Point cathodal stimulation of cardiac tissue was shown previously to produce both a dog-bone shaped virtual cathode transverse to the muscle fibers and two longitudinal virtual anodes. We hypothesize that virtual anodes can cause a region of delayed activation, separating two regions of early activation caused by the ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1326029
更新日期:2000-11-01 00:00:00
abstract::Traditionally, measurement of pulmonary O2 uptake uses mass balance of N2 to correct for differences between inspired and expired volume (V) due to temperature (T) and relative humidity (RH). Often during anesthesia, N2 balance cannot be invoked due to high inspired O2 fraction (FIO2) or nonsteady state conditions. Th...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1312184
更新日期:2000-09-01 00:00:00
abstract::This paper presents an in vitro temperature mapping study of bovine cardiac tissue during radiofrequency ablation. The objectives were to: (i) develop a technique for measuring the spatial and temporal temperature distribution in the tissue and in the blood during ablation, and (ii) use the temperature measurements to...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1310218
更新日期:2000-09-01 00:00:00
abstract::We have studied the dependence of conduction velocity (theta) on extracellular potassium concentration ([K+]o) in a model of one-dimensional conduction using an idealized strand of human atrial cells. Elevated [K+]o in the 5-20 mM range shifts the resting potential (Vrest) in the depolarizing direction and reduces inp...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1308489
更新日期:2000-08-01 00:00:00
abstract::Recent evidence suggests that energy substrate metabolism forms the link between gene expression and contractile function of the heart. This hypothesis draws on three seemingly unconnected observations, made in 1941 by three different investigators. The first gave rise to the concept of the dynamic nature of body cons...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章,评审
doi:10.1114/1.1312187
更新日期:2000-08-01 00:00:00
abstract::This paper discusses the dynamics of the circus movement around a one-dimensional continuous and uniform loop of model cardiac cells. The membrane ionic currents are represented by a modified Beeler-Reuter formulation. The description of the quasiperiodic regimes initiated in a previous paper is completed and their eq...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1289458
更新日期:2000-07-01 00:00:00
abstract::Kiani et al. (Kiani, M. F., A. R. Pries, L. L. Hsu, I. H. Sarelius, and G. R. Cokelet, Am. J. Physics. 266: H1822-H1828, 1994) suggested that blood velocity, hematocrit, and nodal pressures can oscillate spontaneously in large microvascular networks in the absence of biological control. This paper presents a model of ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1306346
更新日期:2000-06-01 00:00:00
abstract::The most widely implanted prosthetic valve is the mechanical bileaflet. Recent clinical experiences suggest that some designs are more prone to thromboembolic episodes than others. This study evaluated the hinge flow and near-field forward flow of the new St. Jude Medical Regent bileaflet mechanical heart valve. Laser...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.297
更新日期:2000-05-01 00:00:00
abstract::High density particle image velocimetry, with spatial resolution of O(1 mm), was used to measure the effect of occluder rebound on the flow field near a Bjork-Shiley Monostrut tilting-disk mitral valve. The ability to measure two velocity components over an entire plane simultaneously provides a very different insight...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.281
更新日期:2000-04-01 00:00:00
abstract::For highly diffusive solutes the kinetics of blood-tissue exchange is only poorly represented by a model consisting of sets of independent parallel capillary-tissue units. We constructed a more realistic multicapillary network model conforming statistically to morphometric data. Flows through the tortuous paths in the...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.273
更新日期:2000-03-01 00:00:00
abstract::In vitro stent-induced thromboembolism was altered by the presence of residual stenoses placed upstream or placed upstream and downstream of the stent. Heparinized (3 micro/ml) bovine blood was gravity fed through a conduit with a deployed coronary stent. Embolism was continuously monitored using a light-scattering mi...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.243
更新日期:2000-02-01 00:00:00
abstract::The statistical distribution of von Mises stress in the trabeculae of human vertebral cancellous bone was estimated using large-scale finite element models. The goal was to test the hypothesis that average trabecular von Mises stress is correlated to the maximum trabecular level von Mises stress. The hypothesis was pr...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1318928
更新日期:2000-01-01 00:00:00
abstract::A model predictive control strategy to simultaneously regulate hemodynamic and anesthetic variables in critical care patients is presented. A nonlinear canine circulatory model, which has been used to study the effect of inotropic and vasoactive drugs on hemodynamic variables, has been extended to include propofol pha...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.255
更新日期:2000-01-01 00:00:00
abstract::This study was aimed at developing a physical model, supported by experimental observations, to describe the formation and growth of microbubbles seen in patients with mitral mechanical heart valves (MHV). This phenomenon, often referred to as high intensity transient signals (HITS), appears as bright, intense, high-v...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.231
更新日期:1999-11-01 00:00:00
abstract::Parameters of physiological models are commonly associated in an input-output experiment with a specific pattern of the system response. This association is often made on an intuitive basis by traditional sensitivity analysis, i.e., by inspecting the variations of model output trajectories with respect to parameter va...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.207
更新日期:1999-09-01 00:00:00
abstract::Intracellular calcium concentration and transmembrane potentials are two important measurements used to study the mechanisms of cardiac activity. Fluorescent dyes have been used to measure these separately but not simultaneously in cardiac tissue. Fluo-3 and Fluo-4 (a recently improved version of Fluo-3) have been use...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.198
更新日期:1999-07-01 00:00:00
abstract::To study the effects of smooth muscle contraction and relaxation on the strain and stress distribution in the vascular wall, a mathematical model was proposed. The artery was assumed to be a thick-walled orthotropic tube made of nonlinear, incompressible elastic material. Considering that the contraction of smooth mus...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.191
更新日期:1999-07-01 00:00:00
abstract::Classically, the primary tool for quantifying the dynamics of vergence and other eye movements has been the main sequence. The main sequence is a plot of peak velocity versus response amplitude and is particularly useful for comparing the dynamics of a large number of eye movements over a range of response amplitudes....
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.162
更新日期:1999-05-01 00:00:00
abstract::Previous research in cellular adhesion has focused primarily on studying isolated cells under conditions where cells do not interact with each other. However, in vivo cells form sheets where both cell-substratum and cell-cell interactions contribute to the overall adhesive behavior. Our understanding of how cell-cell ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.178
更新日期:1999-03-01 00:00:00
abstract::A modified conductance method to determine the cross-sectional areas (CSAs) of arteries in piglets was evaluated in vivo. The method utilized a conductance catheter having four electrodes. Between the outer electrodes an alternating current was applied and between the inner electrodes the induced voltage difference wa...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.219
更新日期:1999-03-01 00:00:00
abstract::The contractile power of the latissimus dorsi muscle (LDM) is used in skeletal muscle cardiac assist (SMCA) to augment the blood pumping ability of a failing heart. The LDM has three anatomically distinct, independently innervate segments-the transverse, oblique, and lateral. There are potential advantages to selectiv...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.164
更新日期:1999-01-01 00:00:00
abstract::Using a three-dimensional propagation model of the human ventricular myocardium, we studied the role of fibrous structure in generating epicardial potential maps. This model represents the myocardium as an anisotropic bidomain with an equal anisotropy ratio, and it incorporates a realistic representation of anatomical...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.73
更新日期:1998-11-01 00:00:00
abstract::Presented is a discussion of steps towards the creation of a database of the microcirculation encompassing anatomical and functional experimental data, and conceptual and computational models. The discussion includes issues of database utility, organization, data deposition, and linkage to other databases. The databas...
journal_title:Annals of biomedical engineering
pub_type:
doi:10.1114/1.112
更新日期:1998-11-01 00:00:00
abstract::The identification of the input to, or kernels of, a system using nonparametric representations and least-squares estimation is becoming increasingly popular. Nonparametric representations avoid making a priori assumptions about the input or having detailed knowledge about the system, and only need to guarantee known ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.110
更新日期:1998-09-01 00:00:00
abstract::The compression of blood vessels by surrounding tissue is an important problem in hemodynamics, most prominently in studies relating to the heart. In this study we consider a long tube of elliptic cross section as an idealization of the geometry of a compressed blood vessel. An exact solution of the governing equation...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.106
更新日期:1998-09-01 00:00:00
abstract::This paper presents the bispectral analysis of the ontogeny of the hippocampal EEG recorded from the dentate gyrus and CA1, the primary sites that generate theta (theta) rhythm. The hippocampal EEG was collected during the vigilance state of rapid eye movement (REM) sleep of freely moving rats at 15, 30 and 90 days of...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.43
更新日期:1998-07-01 00:00:00
abstract::This study evaluates the use of artificial neural networks to estimate stroke volume from pre-processed, thoracic impedance plethysmograph signals from 20 healthy subjects. Standard back-propagation was used to train the networks, with Doppler stroke volume estimates as the desired output. The trained networks were th...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.47
更新日期:1998-07-01 00:00:00
abstract::Spike discharge patterns showing intrinsic oscillations (IOs) have been reported in units in the dorsal cochlear nucleus (DCN) of the decerebrate cat. These oscillations are related to the regularity of a unit's discharge rate and may be important for pitch perception. A DCN unit's regularity can be affected by severa...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.96
更新日期:1998-05-01 00:00:00
abstract::We developed muscle-tendon models incorporating Hill-type structure and length-dependent coupling between activation and velocity. The models were evaluated in electrically stimulated cat soleus muscles. Dynamic model parameters were estimated by a nonlinear parameter estimation algorithm from input-output data obtain...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.93
更新日期:1998-05-01 00:00:00
abstract::The responses of photoreceptor cells to moving stimuli are crucial to understanding motion detection in visual systems. However, these responses are not well characterized quantitatively because they result from a combination of spatial optical behavior in the lens systems with temporal behavior in the phototransducti...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.58
更新日期:1998-03-01 00:00:00
abstract::Asymmetric 75% and 95% area reduction, transparent Sylgard stenotic models were operated under internal carotid artery (ICA) [Womersley parameter, alpha=5.36, Re(mean) =213 and 180, respectively, and Re(peak)=734 and 410, respectively] and left anterior descending coronary artery (LAD) flow wave forms (alpha=2.65, Re(...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.131
更新日期:1998-03-01 00:00:00
abstract::We propose a mathematical model for analyses of the elastic properties of the wall of the outer hair cell (OHC) in the inner ear. The model reflects the properties of the major components of the OHC wall: the subsurface cisternae, the cortical lattice, the plasma membrane, and the radial pillars. The wall is treated a...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.87
更新日期:1998-01-01 00:00:00
abstract::Cerebral blood flow (CBF) increases as arterial oxygen content falls with hypoxic (low PO2), anemic (low hemoglobin) and carbon monoxide (CO) (high carboxyhemoglobin) hypoxia. Despite a higher arterial PO2, CO hypoxia provokes a greater increase in CBF than hypoxic hypoxia. We analyzed published data using a compartme...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.50
更新日期:1998-01-01 00:00:00
abstract::This study was undertaken to investigate the possible origin of some cutaneously recorded higher frequency electrogastrographic signals. Computer modeling of gastric electrical uncoupling was performed using previously described conoidal dipole model. Cutaneous electrogastrograms were simulated after uncoupling was in...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:
更新日期:1997-11-01 00:00:00
abstract::An expression for centerline mean velocity distributions for circular and noncircular confined turbulent jets has been obtained by assuming self-preservation of flow downstream of the jet potential core. It was assumed that the velocity decay was not only dependent on the streamwise distance x in terms of x/d, as in t...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:
更新日期:1997-11-01 00:00:00
abstract::Membrane introduction mass spectrometry has been applied to inert gas measurements in blood and tissue, but gases with low blood solubility are associated with reduced sensitivity. Countercurrent extraction of inert gases from a blood sample into a water carrier phase has the potential to extract most of the gas sampl...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/BF02684170
更新日期:1997-09-01 00:00:00
abstract::We have developed a method for quantifying the complexity of activation patterns observed during ventricular fibrillation (VF) that is based on our previously reported methodology for decomposing epicardial mapping data into a set of isolated wavefronts. One-half second datasets are acquired from a 21 x 24 array of un...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/BF02684160
更新日期:1997-09-01 00:00:00